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Sweat chloride reduction to below the diagnostic threshold for CF (60 mmol/L) is widely regarded as the best surrogate for disease modification, and Alyftreks superiority on that measure provides the clinical narrative for label differentiation from Trikafta

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As shown in Figure 8E , genes related to base excision repair and pyrimidine metabolism, apoptotic process, and ribosome and thermogenesis formed the three main cores of the network

Lee, J.M., Sharifi, M., and Oshman, L