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Unlike insulin, IGF-1 LR3 lacks counter-regulatory mechanisms

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Caffeine, adenosine receptors, and synaptic plasticity

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Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A: Reduced IGF-1 signaling delays age-associated proteotoxicity in mice