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Autophagy 8:17691781 Cardaci S, Filomeni G, Rotilio G, Ciriolo MR (2010) p38(MAPK)/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration

It is also formed naturally in small amounts in the body as an end-product of lipid oxidation and the metabolism of -hydroxyamino acids 18

The most common adverse events were mild-to-moderate headaches, similar in frequency to placebo groups

Gaine PC, Pikosky MA, Martin WF, Bolster DR, Maresh CM, Rodriguez NR

Physical Therapy Science 26 (2), 281284

Supports Pets with GI Disease: Delivers reliable systemic B12 in dogs and cats with inflammatory bowel disease or exocrine pancreatic insufficiency where oral absorption is compromised