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These findings collectively imply that the tested inhibitors, particularly L-NAME and AG, are potent modulators of NGF expression, possibly through interaction with the NO pathway, and may thus represent a viable therapeutic strategy against inflammatory pruritus, Figure 6

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10.1016/j.foodchem.2020.127933 123 RuizD

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The safety database, while extensive for clinical trials, represents limited duration and population diversity compared to the variability encountered in clinical practice