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Also, when AG490 (100 M) was used to block the JAK2-STAT3 pathway, a significant decrease was observed in the expression of JAK2, p-JAK2, STAT3, p-STAT3, and GSTP1 24 h after treating the LoVo cells (Figure 4F)

Faure M, Mettraux C, Moennoz D, et al

NRF2 deficiency replicates transcriptomic changes in Alzheimers patients and worsens APP and TAU pathology

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I.InoguchiT.et al (2008)