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A prospective evaluation of this intervention could include a randomized, clinical trial where younger individuals with risk factors suggestive of PD development later in life, such as mutant S (identified via colonic biopsy 8 ) or clinical predictors 77 , would undergo either truncal vagotomy or a placebo intervention at least 10 years prior to any PD diagnosis 8

Decreases over time varied by income groups, which may indicate different treatment patterns by income groups since 2020

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23 Advanced AI frameworks for therapeutic discovery and spatial modeling AI is also accelerating therapeutic discovery