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E., Galanter, L
Downregulated expression of occludin and zonula occludens-1 is related to increased matrix metalloproteinases levels in diabetes in both rats and humans [37,38], and inhibition of matrix metalloproteinase-9 prevents increased leakage in streptozotocin-induced diabetic mice [39]
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The drug has been, until now, formally marketed towards people with type 2 diabetes, and more recently, it has been given to those combatting obesity
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