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Caprioli, G
Dietary restriction is the most evolutionarily conserved method of lifespan extension 10
Identifying genes associated with the development of human polycystic ovary syndrome
922 In AKT-hyperactivated cancer cells, AKT directly phosphorylates the Ser343 site of TRPML1, inhibits the K552 ubiquitination degradation of TRPML1, and promotes the binding of TRPML1 to ARL8B, leading to lysosomal exocytosis
In PCOS, inflammation and liver fat accumulation lower SHBG, which means more testosterone free to drive symptoms
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