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In the control (placebo) group, side effects occurred in 18% of participants receiving metformin and 19.2% without metformin

They can determine whether an antihistamine or other treatment is required

JAMA 255:26362637 Lauterburg B, Velez M (1988) Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity

doi: 10.1155/2018/9478630 53 SandersMEMerensteinDMerrifieldCAHutkinsR

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This is achieved at the lower dose level and not at the maximum theoretical dose level (20 mg) to incorporate changes required if In-vivo release is much slower than In-vitro release