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A 2024 randomized controlled trial (RCT) with 60 women (ages 40-65) applied 0.1% GHK-Cu cream twice daily for 12 weeks, yielding 31% wrinkle reduction (visia analysis) and 28% improved skin elasticity versus placebo (Kim et al., 2024)

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This synergistic effect arises because a lowcalorie diet reduces fat intake, while it promotes lipolysis and energy expenditure, together achieving more efficient fat reduction and metabolic improvement

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