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With manufacturer coupons and discounts, costs can be lowered to $7000 to $8000/year [[72], [73], [74]]

Non-GLP-1 weight loss medications offer alternatives for patients unable to tolerate GLP-1-related gastrointestinal effects

By helping to regulate blood sugar, these medications support the management of Type 2 diabetes

Circadian rhythm disruption causes a decrease in GLP-1 production.[ref] Blue light exposure at night from screens (phone, TV, tablet) or LED lightbulbs causes circadian rhythm disruption

Other supportive lifestyle interventions Other lifestyle interventions are essential to support individuals using GLP-1s as part of the recommended multicomponent lifestyle programs that are the foundation of obesity treatment [88,171,172]

ESKD, end-stage kidney disease