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The modulatory effect of GNS on intestinal homeostasis (Chao1, Shannon, and Simpson indices, PCoA, and F/B ratio) was demonstrated in an OVX mouse model of osteoporosis, which then restrained the metabolism of microbiota-related TMAO (betaine, choline, creatinine, carnitine, TMA, and TMAO) and the release of pro-inflammatory cytokines [TNF-, IL-6, and granulocyte colony-stimulating factor (G-CSF)], thereby inhibiting bone loss induced by estrogen deficiency

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10.1097/00005768-200104000-00019 93 MatsumotoA

Its funny, because I had learned about this approach as a student, but did not have much understanding of how or even why to use it

doi: 10.3324/haematol.2018.205724 92 HeymannFTackeF