NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Cest la prsence de soufre, apport par la cystine, qui lui confre ses puissantes proprits antioxydantes
doi: 10.3389/fphar.2025.1712903 Received 25 September 2025 Revised 17 November 2025 Accepted 05 December 2025 Published 08 January 2026 Volume 16 - 2025 Edited by Xiufang Huang, Guangzhou University of Chinese Medicine, China Reviewed by Adnan Amin, Yeungnam University, Republic of Korea Hua Yang, China Pharmaceutical University, China Updates Copyright 2026 Ma, Cao, Yang, Zhu, Wang, Liu, Chen, Liu and Zhang
Abbreviations: IR: insulin resistance
If enzymes are deficient, histamine can cross into the bloodstream and cruise around the body willy-nilly, having its way with our cells
in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis (44)
