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First described in 1995, reverse remodeling was observed both in patients with ischemic and nonischemic cardiomyopathy among patients with HFrEF treated with beta-blockers

This is a significant development

doi: 10.1126/science.194.4269.1027

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Pharmacological inhibition of JNK prevented 4-HNE-induced LC3-II formation, suggesting that 4-HNE triggered autophagic responses could be partly attributed to ER stress [155]