For example, they may recommend a dual-mechanism GIP/GLP-1 drug like Zepbound (tirzepatide), which targets two separate hunger receptors instead of just one
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With respect to GLP-1RAs, liraglutide and semaglutide have demonstrated a reduction in the risk of major adverse cardiovascular events (MACE) [16, 17], and, while yet not published, early reports for dulaglutide indicate CV benefits in patients with a wide range of CV risk [18]
Semaglutide has a longer half-life (approximately 7 days) compared to tirzepatide (approximately 5 days), which means the wearing-off effect is less pronounced with semaglutide