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[100] Since many oxidoreductases use NAD + and NADH as substrates, and bind them using a highly conserved structural motif, the idea that inhibitors based on NAD + could be specific to one enzyme is surprising

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While most longevity interventions target single hallmarks of aging, like NAD+ boosters for mitochondrial support [2] or senolytics to clear senescent cells [3], Epitalons appeal lies in its multi-dimensional role in aging biology

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