In GD, the major autoantigen (thyroid-stimulating hormone (TSH)-antibody) is to the receptor for the TSH, which causes overproduction of thyroid hormones, resulting in symptoms such as irritability, rapid heartbeat, weight loss, poor tolerance of heat and bulging eyes (Graves orbitopathy) ( Reference Effraimidis and Wiersinga 4 , Reference Marcocci, Kahaly and Krassas 7 , Reference Brent 8 )
About 77% and 80% of participants in cohorts 1 and 2, respectively, completed the study treatment
Hunger still occurs, but it lacks the urgent, demanding quality that characterized eating before treatment
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Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG, et al
Moreover, this conversion also promotes cell proliferation and stress responses by regulating various signaling pathways including the NADPH oxidase (NOX) family proteins [37, 49]