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Laboratory applications explore the development of combination approaches that target multiple senescence mechanisms simultaneously, while research into biomarkers of senescent cell burden and senolytic administration efficacy enables better experimental monitoring and outcome assessment

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Oral forms exist but are less effective, particularly for gastrointestinal issues, as injected forms seem to yield better clinical responses 6

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However, these side effects are usually mild and go away within a few days

96 Notably, many key proteins in both signalling pathways are localized at synapses and play key roles in synaptic growth and maturation