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Most side effects tend to be mild and temporary

There are also common side effects in all classes of GLP-1s

Semaglutide and Tirzepatide are both GLP-1 receptor agonists, with Tirzepatide having additional action on and a higher affinity for glucose-dependent insulinotropic polypeptide (GIP) receptors

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Studies also show that insulin alone cannot effectively manage diabetes because it doesn't address GCG's catabolic effects, whereas treatments targeting GCG suppression, such as leptin or GCG receptor antibodies, could lead to better glucose regulation