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To examine the effect of small studies, publication bias was assessed using a comparison-adjusted funnel plot and Eggers test

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Despite the fact that peptide ligands are relatively flexible and have a lower binding affinity to receptors compared with antibodies, the use of peptides in theranostic nanomedicine offers advantages because they are smaller, have reduced immunogenicity, have high multivalency, penetrate deep into tumors, are simpler to synthesize, and are cost-effective in production

Conversely, estrogen therapy can affect glucose metabolism and insulin sensitivity, though effects vary based on formulation, dose, and route of administration