More importantly, we discovered the novel mechanism that LPS stimulation triggered a classic protein kinase C (cPKC)-dependent phosphorylation of GSTP and translocation of GSTP from cytoplasm to nucleus
Peariso K, Goulding CW, Matthews RG, Penner-Hahn J
However, a number of studies have indicated that peroxisomal -oxidation has a significantly lower capacity than that of mitochondrial -oxidation, particularly in muscle ( Reference Henderson and Tocher 63 Reference Fryland, Lie and Berge 65 )
Therefore, suppression of the NF-B pathway could inhibit tumor resistance to apoptosis
, Lorkowski, S
Lack of GSH means GSH cannot protect the cell from the reactive oxygen species, which damage the cell membrane by oxidizing the protein and lipid constituents