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Data extraction The included studies were reviewed to extract data related to the type of model, sample size, type of drug, dosing interventions, parameters measured against pre-defined objectives, methodological steps, findings, and contextual factors

For patients requiring additional therapeutic effect, the dose may be increased to 1 mg of semaglutide weekly after at least four weeks at the 0.5 mg dose

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58 A realistic hypothesis is that this specific enzyme could behave similarly also in other mammalian species

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