Furthermore, nicotinamide adenine dinucleotide phosphate (NADPH), derived from niacin, is crucial in antioxidant defense mechanisms, by aiding in the regeneration of other antioxidants, such as glutathione (51)
3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )
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