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The use of adjuvant doxorubicin-based cytotoxic chemotherapy for MPNST has also been debated, with several studies failing to show a survival benefit of chemotherapy in the treatment of MPNST [9, 27, 28]

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A recent meta-analysis of 12 observational studies found that higher dietary intake of vitamin B 12 was associated with a 23% lower risk of depression compared to lower intakes, but stratifying the data revealed a significant protective association in females, not in males (99)