Long-term safety data matters
GLP-1 receptor activation slows gastric emptying, which reduces the rate of postprandial glucose absorption and attenuates the postprandial glucose excursion an effect that becomes measurable within the first weeks of the escalation phase even at the 2mg starting dose
Mounjaro (tirzepatide) uniquely targets both GLP-1 and GIP receptors, potentially offering more substantial weight reduction and improved glycemic control compared to other GLP-1RAs that only target the GLP-1 receptor, such as Ozempic (semaglutide)
Patients using compounded GLP-1s pay out-of-pocket
Patients should place the medication toward the back of a refrigerator shelf, away from the freezer compartment, to minimize the risk of accidental freezing
Their clinical application in diabetes is recognized, but the mechanism by which they lower blood glucose is not fully understood