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Primary Handling Editor: Jennifer Sargent, in collaboration with the Nature Medicine team

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Beyond appetite rebound, abrupt stops may trigger increased cravings for high-calorie, high-sugar foods because your dopamine response to food reward intensifies during the adjustment period

A healthcare provider can help determine the most appropriate treatment duration based on individual goals and results

Meal #9: Tuna Salad on Crackers Ingredients: 1 can (5 oz) water-packed tuna 1 tablespoon light mayo Diced celery, onion 6 whole grain crackers Why it works: Extremely high protein for minimal calories

Those on the 10 mg dose lost 19.5% of their body weight