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The practical takeaway for a beginner is that these are two distinct compounds with two distinct research stories

In rats, long-term low-dose PS-NPs exposure reduced amygdalar metabolites-N-acetylserotonin, N-acetyl-L-tyrosine, and 4-aminobutyric acid, suggesting impaired neurotransmitter metabolism (Jiang et al., 2023)

Discovered in 1977 (Schoenenberger)

But getting enough folate from what you eat plays a bigger role in folate levels than having MTHFR gene variants

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