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2020;doi:10.1038/s41572-020-0160-6
The binding of IGFs to their receptors activates both MAPK and PI3K-AKT pathways, which results in downstream cellular effects (such as cellular proliferation, anti-apoptosis, and differentiation actions) through other downstream molecules ( IRS 1-4 and other signaling proteins, such as Shc, bind to the IGF-1R at the extracellular subunit as a result of the binding of IGF-I and IGF-II ( Recent research has shown that the IGF-1R (and IR) can migrate to the nucleus in both healthy and cancerous cells through mechanisms that are still being fully elucidated, although sumoylation is thought to be one method
Patients who have this type of procedure typically can go back to work faster than those who have other types
The addition of GIP agonism is what separated tirzepatide from pure GLP-1 drugs, and researchers tracking the progression from semaglutide to tirzepatide to retatrutide can see how each additional receptor adds another layer of metabolic benefit
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