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Serum B12 reference ranges vary between laboratories, but generally, levels below 148 pmol/L are considered deficient, whilst levels between 148258 pmol/L are regarded as borderline and may warrant further investigation or a trial of treatment, particularly if symptoms are present

For a 180 lb individual, this works out to roughly 0.45 to 0.9 mg daily, aligning with the commonly used ranges

ICH Q2(R2): Validation of Analytical Procedures

Epithalon Laboratory and Human-Cell Research Cell experiments generate hypotheses but do not establish clinical anti-ageing effects

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