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Accessed August 17, 2023

The escalation schedule exists because your body needs time to adjust to each dose level

Severe or intolerable side effects may be a reason to switch GLP-1 medications

doi: 10.1056/NEJMc2109509

It is also, per recent mechanistic work, responsible for PCSK9 degradation, which is the likely pathway behind the LDL cholesterol reductions seen in TRIUMPH-4

The steps below come from the DailyMed retatrutide label and standard subcutaneous injection technique from MSKCC