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In parallel, ADE can elevate viremia by enhancing viral infectivity in Fc-receptor-expressing leukocytes, leading to an increased presence of the circulating virus and virion-associated EIII, thereby intensifying the impact of the first hit (Figure 2, upper panel, black box: ADE-aid viremia)

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It is conceivable that a decrease in the binding affinity of IGF-1 LR3 for IGFBPs might affect its bioavailability, potentially reducing its duration of action