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The bottom line is that both medications have benefits and drawbacks, and your healthcare provider will help you find the one that works best for you

Some studies push this even higher, suggesting 1.6 to 2.3 grams per kilogram of fat-free mass for optimal lean tissue preservation

In one clinical trial funded by Eli Lilly, participants who took Tirzepatide 5.0 mg lost 16.1 kg of body weight, participants who took Tirzepatide 10 mg lost 22.2 kg of body weight, and participants who took Tirzepatide 15 mg lost 23.6 kg of body weight, while only 2.4 kg weight loss was observed in participants taking placebo

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have demonstrated that calorie restriction, but not metformin (in the diet 300 mg/kg/day), extended lifespan in male Fisher-344 rats, leading to the conclusion that metformin is not a calorie restriction mimetic (CRM) (78) (see Table 1 for a summary)