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rather, its effectiveness may diminish

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In humans, large proportions of orally administered d-allulose are absorbed and subsequently excreted via the urine without being metabolized 14

Saulsberry WJ, Coleman CI, Mearns ES, Zaccaro E, Doleh Y, Sobieraj DM

However, some providers may prescribe it for off-label use

Paracellular transport across the tight junction can occur via the pore pathway or the leak pathway, which have distinct size-selectivity and charge-selectivity and are differentially regulated by immune signalling