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The frequency of B12 IV treatments can vary based on individual needs and health goals

Nature 477 , 211215 (2011)

excessive eating) Lower energy expenditure High cortisol levels Abnormal glucose and lipid metabolism Infertility of the hypogonadotropic type Leptin mutations in humans can also cause leptinopenia and early-onset obesity

Its an ingredient whose safety hasnt been questioned so far by anyone (at least not that we know about)