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Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta)

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[65] indicated elevated blood homocysteine levels in individuals with Type 2 diabetes mellitus (T2DM), particularly among those with diabetic nephropathy (DN) and diabetic retinopathy (DR), but the precise role of homocysteine in the development of T2DM and its associated complications remains ambiguous

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Also, for speeding up the metabolic process, try splitting the dose if you have a slow metabolism