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Diabetes mellitus: Health and wealth threat

However, DPP-4 can interact with the integral membrane protein, caveolin-1 (91), which is expressed in various cell types, including adipocytes (92), and may be upregulated in obesity (93)

Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, Edwards R, Agarwal R, Bakris G, Bull S, Cannon CP, Capuano G, Chu PL, de Zeeuw D, Greene T, Levin A, Pollock C, Wheeler DC, Yavin Y, Zhang H, Zinman B, Meininger G, Brenner BM, Mahaffey KW

doi: 10.1371/journal.pone.0169851 15 DowleyA.O'DohertyJ

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These findings reinforce the long-term impact of semaglutide-based treatmentsdeveloped by Novo Nordisk, the manufacturer behind Ozempic and Wegovy in managing both diabetes and obesity