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Who Should Pay Attention to This Research This trial is most immediately relevant to: Older adults with known risk factors for cognitive decline particularly those with obesity, type 2 diabetes, high blood pressure, or cardiovascular disease who are also candidates for GLP-1 therapy Researchers and clinicians working at the intersection of metabolic health and cognitive aging People currently taking GLP-1 medications for diabetes or obesity who have wondered whether the drugs may offer cognitive benefits Caregivers and family members of older adults who are monitoring cognitive health and looking for potential preventive strategies Symptoms and Warning Signs to Watch For The PROTECT-Cog Study is designed for prevention it targets people who are at risk for cognitive decline but have not yet been diagnosed with dementia

Early optimism in the use of GLP-1 therapies for Parkinsons disease has been tempered by the recent failure of a Phase III exenatide trial which did not show any benefits of slowing Parkinsons progression 10

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