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86 for a description of the general role of cardiac fibroblasts in the innate response to myocardial infarction, as well as their phenotypic plasticity and involvement in extracellular matrix production

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178 Compared with traditional single-target agents, SIRT1 activators simultaneously modulate several critical pathways, including metabolism, immune responses, and oxidative balance, offering a network reprogramming therapeutic advantage, particularly in the early stages of the disease when multiple processes are synergistically dysregulated