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However, cases of concomitant deficiencies involving B 12 with either B 1 or B 6 remain rare, suggesting distinct risk factors and clinical presentations for each vitamin deficiency

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Outside the CNS low level HRH3 expression has been found in the gastrointestinal and cardiovascular systems and in bronchial cells of the lungs

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Curiously, the strongest anxiolytic effect came from the smallest administered dose of 0.5 mcg/kg body weight, whereas larger doses had smaller effects on anxiety [12]