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12 Abnormally high levels of the neurofilament light chain protein in blood, a biomarker of damaged neurons, were found to start an average of 22 years before the median estimated age of symptom onset

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There is a link between apoptotic markers and mitochondrial proteins, with a significant negative correlation between mitochondrial fission/fusion proteins and apoptotic markers in peripheral blood cells of people with BD [57]

Molecular Aspects of Medicine, 30(1-2), 1-12.

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Potential Benefits (preclinical) Fat metabolism: Animal models report reductions in fat mass while lean muscle is preserved [5] [6]