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Any patient with serum acetaminophen poisoning in the possible or probable hepatotoxicity range should be treated with NAC

King MA, Bradshaw S, Chang AH, Pintar JE, Pasternak GW

doi: 10.3389/fnut.2025.1754492 Received 26 November 2025 Revised 20 December 2025 Accepted 24 December 2025 Published 21 January 2026 Volume 12 - 2025 Edited by Javier Diaz-Castro, University of Granada, Spain Reviewed by Mahsa Rezazadegan, Isfahan University of Medical Sciences, Iran Soroush Taherkhani, Iran University of Medical Sciences, Iran Updates Copyright 2026 Poon, Li, Schweitzer and Akefe

Starting in your mid-20s, your body's natural collagen production begins to decline at a rate of about 11.5% per year

If your skin is sensitive, patch test first and consider starting with a lower frequency or lower percentage