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Its substrate specificity is also very high because activity on other hexose phosphates (e.g., mannose 6-phosphate or galactose 6-phosphate) is negligible

Candidacy also considers previous weight loss attempts, metabolic health markers, and medication history

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Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

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demonstrated, in addition to higher weight loss in the group treated with high-dose liraglutide 3.0 mg/day for 32 weeks, significant improvements not only of fasting glucose and HOMA-IR, but also of the post-load glucose measured by OGTT, OGTT-derived insulin sensitivity index (SIOGTT), and corrected the early insulin response to a glucose challenge (IGI/HOMA) compared to placebo [62]