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However, the main muscle anabolic effects of GH are believed to be indirectvia inducing the hepatic generation of IGF-1 triggering the IGF-1-Akt-mTOR pathway
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Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)
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