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Plasma concentrations of GHK decline with age, from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60

Diabetes Care 15:dc202887 Hiruma S, Shigiyama F, Hisatake S, Mizumura S, Shiraga N, Hori M, Ikeda T, Hirose T, Kumashiro N (2021) A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with early-stage type 2 diabetes: the ASSET study

These trends underscore a rising need for advancements in GLP1 delivery systems and broader patient access initiatives

GLP-1 enhances glucose metabolism by stimulating insulin secretion when blood sugar levels rise, inhibiting glucagon release, and slowing gastric emptying to regulate nutrient absorption

Criteria for its use are shown in Box 1