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doi: 10.1210/jc.2010-1587

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This was done using a sandwich ELISA assay which employed a purified antibody to collagen type I

If you see persistent pain, redness, or itching at the site of the injection, mild diarrhea, swelling sensation in your body, or temporary itching in your skin, contact your doctor immediately

Another reasonable trigger point is when you reach a body fat percentage where the remaining fat is concentrated in specific areas rather than distributed evenly