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This article examines the science, safety considerations, and evidence-based alternatives for patients considering GLP-1-related therapies

GLP-1 receptors are located in the brain, and GLP-1 is created in the brain in preproglucagon neurons

While earlier GLP-1 drugs have decades of data behind them, newer high-potency agonists and multi-agonist combinations will require extended monitoring as their use expands

Plenity side effects Common side effects include: Bloating Gas Abdominal pain Plenity costs The company that makes Plenity, Gelesis, sells a 4-week supply with a prescription for $98

GLP-1 Drugs May Boost Mood via the Microbiome GLP-1 therapy reduced depression-like behaviors in mice by altering the gut microbiome

The strategy for these patients involves achieving target weight, stabilizing on a maintenance dose, then implementing a structured taper timed to allow the recommended washout period before conception