Nat Rev Drug Discov 24 , 631650 (2025)
Up to about the first 3 months of life (nutritional phase 1a), PWS newborn is hypotonic, manifests feeding and suckling deficits, and feeding via nasogastric or gastric tube is often required to ensure sufficient nutritionafterwards up to 1218 months, (nutritional phase 1b) the feeding improves, and the infants begin to exhibit normal appetite and growth [27]
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It has been suggested that antioxidant supplementation may only improve performance when endogenous levels are already depleted, and after reaching normal concentrations, no further benefit is seen [35]
