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After adding either the cGASSTING pathway inhibitor C-176 or GLP-1RAs, the cGAS-STING signaling pathway was inhibited effectively accompanied with suppression of chondrocyte ferroptosis, inflammatory factor expression, and osteophyte formation on articular surfaces, and enhancement of cartilage repair, reinforcing a causal link between cGASSTING activation and chondrocyte ferroptosis in RA

Flavonoids, which are widely distributed in fruits and vegetables, represent a class of plant components that are effective as anti-inflammatories (21)

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25 Horvath A, Bossis I, Giatzakis C, Levine E, Weinberg F, Meoli E, et al