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Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate

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Third, MR estimates, although less confounded, are less precise than conventional observational studies, because the genetic variants only explain a small proportion of the variance in exposure [38]

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Changes in GRK2 Localization Impact Endothelial Cell Activity In addition to the expression level, the localization in the membrane (memb) or cytoplasm (cyt) of GRK2 is another critical factor that determines which proteins at a particular location GKR2 interacts with, and eventually influences GPCR signaling and desensitization (15)