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Furthermore, upregulation of their differentiation capacity was noted [199]

Moreover, we discuss the potential of therapeutic strategies targeting the biological functions of selenium and selenoproteins for OA treatment

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Nausea is the most common side effect, affecting 15-40% of patients, along with mild abdominal discomfort, bloating, or changes in appetite

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The body's homeostatic mechanisms actively defend against sustained weight loss, making pharmacological support withdrawal a vulnerable period requiring proactive management strategies and realistic expectations about the challenges ahead